Interspecies communication in bacteria

被引:406
作者
Federle, MJ [1 ]
Bassler, BL [1 ]
机构
[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
关键词
D O I
10.1172/JCI200320195
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Until recently, bacteria were considered to live rather asocial, reclusive lives. New research shows that, in fact, bacteria have elaborate chemical signaling systems that enable them to communicate within and between species. One signal, termed AI-2, appears to be universal and facilitates interspecies communication. Many processes, including virulence factor production, biofilm formation, and motility, are controlled by AI-2. Strategies that interfere with communication in bacteria are being explored in the biotechnology industry with the aim of developing novel antimicrobials. AI-2 is a particularly attractive candidate for such studies because of its widespread use in the microbial kingdom.
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收藏
页码:1291 / 1299
页数:9
相关论文
共 65 条
[1]   AUTOCRINE REGULATION OF TOXIN SYNTHESIS BY STAPHYLOCOCCUS-AUREUS [J].
BALABAN, N ;
NOVICK, RP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) :1619-1623
[2]   INTERCELLULAR SIGNALING IN VIBRIO-HARVEYI - SEQUENCE AND FUNCTION OF GENES REGULATING EXPRESSION OF LUMINESCENCE [J].
BASSLER, BL ;
WRIGHT, M ;
SHOWALTER, RE ;
SILVERMAN, MR .
MOLECULAR MICROBIOLOGY, 1993, 9 (04) :773-786
[3]   SEQUENCE AND FUNCTION OF LUXO, A NEGATIVE REGULATOR OF LUMINESCENCE IN VIBRIO-HARVEYI [J].
BASSLER, BL ;
WRIGHT, M ;
SILVERMAN, MR .
MOLECULAR MICROBIOLOGY, 1994, 12 (03) :403-412
[4]   MULTIPLE SIGNALING SYSTEMS CONTROLLING EXPRESSION OF LUMINESCENCE IN VIBRIO-HARVEYI - SEQUENCE AND FUNCTION OF GENES ENCODING A 2ND SENSORY PATHWAY [J].
BASSLER, BL ;
WRIGHT, M ;
SILVERMAN, MR .
MOLECULAR MICROBIOLOGY, 1994, 13 (02) :273-286
[5]   Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi [J].
Bassler, BL ;
Greenberg, EP ;
Stevens, AM .
JOURNAL OF BACTERIOLOGY, 1997, 179 (12) :4043-4045
[6]   LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence [J].
Burgess, NA ;
Kirke, DF ;
Williams, P ;
Winzer, K ;
Hardie, KR ;
Meyers, NL ;
Aduse-Opoku, J ;
Curtis, MA ;
Cámara, M .
MICROBIOLOGY-SGM, 2002, 148 :763-772
[7]   Structural identification of a bacterial quorum-sensing signal containing boron [J].
Chen, X ;
Schauder, S ;
Potier, N ;
Van Dorsselaer, A ;
Pelczer, I ;
Bassler, BL ;
Hughson, FM .
NATURE, 2002, 415 (6871) :545-549
[8]   Signaling system in Porphyromonas gingivalis based on a LuxS protein [J].
Chung, WSO ;
Park, Y ;
Lamont, RJ ;
McNab, R ;
Barbieri, B ;
Demuth, DR .
JOURNAL OF BACTERIOLOGY, 2001, 183 (13) :3903-3909
[9]   BIOFILMS, THE CUSTOMIZED MICRONICHE [J].
COSTERTON, JW ;
LEWANDOWSKI, Z ;
DEBEER, D ;
CALDWELL, D ;
KORBER, D ;
JAMES, G .
JOURNAL OF BACTERIOLOGY, 1994, 176 (08) :2137-2142
[10]   The involvement of cell-to-cell signals in the development of a bacterial biofilm [J].
Davies, DG ;
Parsek, MR ;
Pearson, JP ;
Iglewski, BH ;
Costerton, JW ;
Greenberg, EP .
SCIENCE, 1998, 280 (5361) :295-298