Understanding the generation and function of memory T cell subsets

被引：346

作者：

Lanzavecchia, A ^{[1
]}

Sallusto, F ^{[1
]}

机构：

[1] Inst Biomed Res, CH-6500 Bellinzona, Switzerland

来源：

CURRENT OPINION IN IMMUNOLOGY | 2005年 / 17卷 / 03期

关键词：

D O I：

10.1016/j.coi.2005.04.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Memory T cells can be broadly divided into central memory and effector memory subsets, which are endowed with different capacities to home to lymphoid or non-lymphoid tissues, to proliferate in response to antigen or cytokines and to perform effector functions. In the past few years progress has been made in understanding the properties of these memory T cell subsets and, in particular, the signals required for their generation and maintenance. Collectively these data point to a critical role of central memory T cells in conferring long-term immunity.

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页码：326 / 332

页数：7

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