gp49BI-αvβ3 interaction inhibits antigen-induced mast cell activation

被引:79
作者
Castells, MC [1 ]
Klickstein, LB
Hassani, K
Cumplido, JA
Lacouture, ME
Austen, KF
Katz, HR
机构
[1] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA
关键词
D O I
10.1038/87749
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We have identified the integrin alpha (v)beta (3) as a ligand for mouse gp49B1,thus identifying a new class of ligand for a member of the family of inhibitory immunoreceptors that bear C2-type immunoglobulinlike domains,The specific interaction was shown by both cell-protein and cell-cell binding assays, In addition, we found that the interaction of alpha (v)beta (3) with gp49BI on bone marrow-derived mouse mast cells inhibited antigen-induced immunoglobulin E-mediated cell activation. Because neither gp49BI nor alpha (v)beta (3) exhibit substantive allelic variation, their newly appreciated interaction may reflect an innate pathway for down-regulating the activity of mast cells.
引用
收藏
页码:436 / 442
页数:7
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