Oxidative stress and antioxidants in interstitial lung disease

被引:44
作者
Bast, Aalt [1 ]
Weseler, Antje R. [1 ]
Haenen, Guido R. M. M. [1 ]
den Hartog, Gertjan J. M. [1 ]
机构
[1] Maastricht Univ, Fac Hlth Med & Life Sci, Dept Pharmacol & Toxicol, NL-6200 MD Maastricht, Netherlands
关键词
antioxidants; interstitial lung disease; N-acetylcysteine; oxidative stress; IDIOPATHIC PULMONARY-FIBROSIS; GASTROESOPHAGEAL-REFLUX; N-ACETYLCYSTEINE; CYSTIC-FIBROSIS; PIRFENIDONE; SUPEROXIDE; ACTIVATION; QUERCETIN; RESPONSES; THERAPY;
D O I
10.1097/MCP.0b013e32833c645d
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Purpose of review The cause of interstitial lung diseases (ILDs) such as lung fibrosis or sarcoidosis is still largely unknown. Pharmacotherapeutic treatment in ILD lacks a firm mechanistic molecular basis. A striking paradox is that ILDs result in a shortage of oxygen and that at the same time reactive oxygen species are responsible for the tissue damage in ILDs. The realization of the importance of reactive oxygen species offers new possibilities for therapeutic interventions. Recent findings Remarkably, the two drugs that have been shown to be the most effective ones in the treatment of lung fibrosis are in fact antioxidants that protect against the toxicity of oxygen. Redox cycling drugs that are notorious oxygen radical generators may also cause ILD. Apart from lung fibrosis, sarcoidosis also has recently been associated with the occurrence of oxidative stress. Summary The limited number of ILD patients necessitates multicenter trials to obtain enough power to reach clinically relevant data. The specific fibrotic toxicity of O(2)(center dot-) might be a lead in the development of new therapies and of suggesting optimal antioxidant dietary regimes.
引用
收藏
页码:516 / 520
页数:5
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