Studies in marine macrolide synthesis:: Stereocontrolled synthesis of the C1-C11 and C15-C27 subunits of aplyronine A

被引：29

作者：

Paterson, I ^{[1
]}

Cowden, CJ ^{[1
]}

Woodrow, MD ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(98)01191-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The aplyronine C-1-C-11 subunit 4, containing 4 stereocentres and the (E,E)-diene system, was prepared in 7 steps from ethyl ketone (R)-8 using a boron-mediated anti aldol reaction. The corresponding C-15-C-27 subunit 5, containing 6 stereogenic centres and an (E)-alkene, was obtained in 10 steps from ketone (S)-14 using a tin(II)-mediated syn aldol reaction and CBS enone reduction. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：6037 / 6040

页数：4

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