Efficient synthesis of 3-aroylcinnolines from aryl methyl ketones

被引：67

作者：

Al-Awadi, NA ^{[1
]}

Elnagdi, MH ^{[1
]}

Ibrahim, YA ^{[1
]}

Kaul, K ^{[1
]}

Kumar, A ^{[1
]}

机构：

[1] Kuwait Univ, Dept Chem, Safat 13060, Kuwait

来源：

TETRAHEDRON | 2001年 / 57卷 / 08期

关键词：

2-arylhydrazono-3-oxopropanal; cinnolines; aryl methyl ketones;

D O I：

10.1016/S0040-4020(00)01141-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 3-aroylcinnolines starting from the appropriate aryl methyl ketones is described. The latter were converted in two steps to the corresponding 3-oxo-3-aryl-2-arylhydrazonopropanals, which upon acid catalyzed cyclization in cone. sulfuric acid or polyphosphoric acid (PPA) led to the corresponding 3-aroylcinnolines. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1609 / 1614

页数：6

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