DDB complexities

被引：68

作者：

Wittschieben, BO ^{[1
]}

Wood, RD ^{[1
]}

机构：

[1] Univ Pittsburgh, Inst Canc, Hillman Canc Ctr, Pittsburgh, PA 15213 USA

来源：

DNA REPAIR | 2003年 / 2卷 / 09期

关键词：

DNA damage-binding protein; cockayne syndrome group A (CSA); xeroderma pigmentosum;

D O I：

10.1016/S1568-7864(03)00113-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A group of recent publications contribute new insights concerning the role of the DNA damage-binding protein complex (DDB) in DNA repair. Mutations in the 48 kDa DDB2 subunit are now found in all confirmed cases of xeroderma pigmentosum complementation group E. Several studies have reported a connection between the 127 kDa DDB1 subunit and proteins involved in ubiquitin-mediated proteolysis. One such multiprotein complex containing DDB1 and DDB2 is closely related to a complex containing DDB1 and the Cockayne syndrome group A (CSA) protein. There is accumulating evidence for several levels of cellular regulation of DDB, including translocation to the nucleus, proteolytic degradation of DDB2 protein, and transcriptional induction of DDB2 mRNA. Although the mechanism is not yet known, it appears that DDB assists in nucleotide excision repair in chromatin. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：1065 / 1069

页数：5

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