Long-term results of kidney transplantation from HCV-Positive donors

被引：20

作者：

Kasprzyk, T. ^{[1
]}

Kwiatkowski, A. ^{[1
]}

Wszola, M. ^{[1
]}

Ostrowski, K. ^{[1
]}

Danielewicz, R. ^{[1
]}

Domagala, P. ^{[1
]}

Malkowski, P. ^{[1
]}

Fesolowicz, S. ^{[1
]}

Nosek, R. ^{[1
]}

Czerwinski, J. ^{[1
]}

Trzebicki, J. ^{[1
]}

Durlik, M. ^{[1
]}

Paczek, L. ^{[1
]}

Patrzalek, D. ^{[1
]}

Rowinski, W. ^{[1
]}

Chmura, A. ^{[1
]}

机构：

[1] Med Univ Wroclaw, Dept Vasc Gen & Transplant Surg, Wroclaw, Poland

来源：

TRANSPLANTATION PROCEEDINGS | 2007年 / 39卷 / 09期

关键词：

HEPATITIS-C-VIRUS; INFECTION; PERFUSION; PATIENT;

D O I：

10.1016/j.transproceed.2007.09.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Due to the shortage of organs for transplantation, procurement of kidneys from marginal donors is inevitable. Not infrequently, these donors are infected with hepatitis C virus (HCV). Aim. We sought to determine the effect of transplanting kidneys from anti-HCV-positive donors to anti-HCV-positive recipients. Patients and Methods. Among 765 procedures between 1994 and 2006, 259 kidney recipients were anti-HCV-positive, including 60 who received kidneys from anti-HCVpositive donors (HCV+/HCV+ group) and the others, from seronegative donors (HCV-/HCV+ group). The control group of 506 seronegative recipients received kidneys from seronegative donors (HCV-/HCV- group). All kidneys from anti-HCV-positive donors were preserved with machine perfusion. We investigated recipient liver function tests (LFTs; alanine aminotrasferase, aspartate aminotransferase; alkaline phosphatase, and bilirubin), graft survival, and patient survival. Results. No significant difference was observed between the groups among the biochemistry results (LFTs, creatinine at 5 years). No significant differences, were observed in patient survival, graft survival, or number of patients returning to dialysis. Conclusion. Transplantation of kidneys from HCV-positive donors to HCV-positive recipients did not influence long-term liver function, or long-term renal allograft function. This strategy enhances the availability of transplantation as means of end-stage renal disease treatment.

引用

页码：2701 / 2703

页数：3

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