Role of β2-microglobulin in the immune response in renal osteodystrophy

被引：4

作者：

Balint, E ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Cell Biol, Worcester, MA 01655 USA

来源：

SEMINARS IN DIALYSIS | 2001年 / 14卷 / 02期

关键词：

D O I：

10.1046/j.1525-139x.2001.00029.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Renal osteodystrophy is the major cause of skeletal morbidity in dialysis patients. It is characterized by beta (2)-microglobulin (beta M-2) amyloid deposition at the osteoarticular sites and a destructive arthropathy. beta M-2 is present on the surface of all nucleated cells as the small extracellular subunit of the major histocompatibility complex (MHC) class I molecule and actively participates in the immune response. Accumulating evidence suggests that beta M-2 plays a key role in the development of renal osteodystrophy through a T cell-mediated inflammatory immune mechanism.

引用

页码：113 / 116

页数：4

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