Bone morphogenetic proteins and their receptors in the eye

被引:86
作者
Wordinger, Robert J.
Clark, Abbot F.
机构
[1] Univ N Texas, Hlth Sci Ctr, Dept Cell Biol & Genet, Ft Worth, TX 76107 USA
[2] Alcon Labs Inc, Glaucoma Res, Ft Worth, TX 76134 USA
关键词
bone morphogenetic proteins; bone morphogenetic protein receptors; bone morphogenetic protein signaling; ocular tissues;
D O I
10.3181/0510-MR-345
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The human genome encodes at least 42 different members of the transforming growth factor-P superfamily of growth factors. Bone morphogenetic proteins (BMPs) are the largest subfamily of proteins within the transforming growth factor-P superfamily and are involved in numerous cellular functions development, morphogenesis, cell proliferation, apoptosis, and extracellular matrix synthesis. This article first reviews BlVlPs and BMP receptors, BMP signaling pathways, and mechanisms controlling BMP signaling. Second, we review BMP and BMP receptor expression during embryonic ocular development/ future as y, u ssues. differentiation and in adult ocular research directions with respect to BMP, BMP receptors, and ocular tissues are suggested.
引用
收藏
页码:979 / 992
页数:14
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