Modafinil does not affect serotonin efflux from rat frontal cortex synaptosomes: comparison with known serotonergic drugs

被引：9

作者：

Ferraro, L

Tanganelli, S

Fuxe, K

Bebe, BW

Tomasini, MC

Rambert, FA

Antonelli, T

机构：

[1] Univ Ferrara, Dept Clin & Expt Med, Pharmacol Sect, I-44100 Ferrara, Italy

[2] Karolinska Inst, Dept Neurosci, Stockholm, Sweden

[3] Lab L Lafon, Maisons Alfort, France

来源：

BRAIN RESEARCH | 2001年 / 894卷 / 02期

关键词：

modafinil; fluoxetine; DL-Fenfluramine; paroxetine; serotonin transmission; sleep;

D O I：

10.1016/S0006-8993(01)02000-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Modafinil did not affect spontaneous and K+-evoked [H-3]5-HT efflux from cortical synaptosomes while it increased K+-evoked tritium efflux from cortical slices, an action that became stronger in the presence of paroxetine. In contrast, DL-fenfluramine and fluoxetine were able to enhance spontaneous and/or K+-evoked tritium efflux from synaptosomes and slices. These results suggest that modafinil does not affect 5-HT transmission from cortical synaptosomes and that its 5-HT releasing action is different from that of DL-fenfluramine and fluoxetine. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：307 / 310

页数：4

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