A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation

被引：50

作者：

Duran, Charity G. ^{[1
]}

Burbank, Allison J. ^{[1
]}

Mills, Katherine H. ^{[1
]}

Duckworth, Heather R. ^{[1
]}

Aleman, Maria M. ^{[1
]}

Kesic, Matthew J. ^{[2
]}

Peden, David B. ^{[1
]}

Pan, Yinghao ^{[3
]}

Zhou, Haibo ^{[3
]}

Hernandez, Michelle L. ^{[1
,4
]}

机构：

[1] Univ N Carolina, UNC Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC 27599 USA

[2] Methodist Univ, Dept Phys Therapy, Fayetteville, NC USA

[3] Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

[4] UNC Sch Med, Div Allergy Immunol & Rheumatol, 104 Mason Farm Rd,CB 7310, Chapel Hill, NC 27599 USA

来源：

RESPIRATORY RESEARCH | 2016年 / 17卷

关键词：

Sulforaphane; NRF2; Ozone; Airway inflammation; Antioxidants; INHALED ENDOTOXIN CHALLENGE; BROCCOLI SPROUT EXTRACT; HEALTHY-VOLUNTEERS; OXIDATIVE STRESS; GENE-EXPRESSION; RECRUITMENT; ENZYMES; CELLS;

D O I：

10.1186/s12931-016-0406-8

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2). In this proof-of-concept clinical study, we show that supplementation of SFN with broccoli sprout homogenate in healthy human subjects did not induce expression of antioxidant genes or protect against neutrophilic airway inflammation in an ozone-exposure model. Therefore, dietary sulforaphane supplementation is not a promising candidate for larger scale clinical trials targeting airway inflammation.

引用

页数：4

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