Relation between plasma adiponectin, high-sensitivity C-reactive protein, and coronary plaque components in patients with acute coronary syndrome

被引：63

作者：

Otake, Hiromasa ^{[1
]}

Shite, Junya ^{[1
]}

Shinke, Toshiro ^{[1
]}

Watanabe, Satoshi ^{[1
]}

Tanino, Yusuke ^{[1
]}

Ogasawara, Daisuke ^{[1
]}

Sawada, Takahiro ^{[1
]}

Hirata, Ken-ichi ^{[1
]}

Yokoyama, Mitsuhiro ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Cardiovasc & Resp Med, Kobe, Hyogo 657, Japan

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2008年 / 101卷 / 01期

关键词：

D O I：

10.1016/j.amjcard.2007.07.041

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present study investigated the relation between plasma high-scrisitivity C-reactive protein (hs-CRP) and adiponectin and coronary plaque components in patients with acute coronary syndrome (ACS). Previous studies showed a pivotal role of inflammation in the progression of atherosclerosis and the prognostic value of several biomarkcrs. However, relations among inflammatory biomarkers and plaque characteristics were unknown. Ninety-three culprit plaques (ACS n = 50, non-ACS n = 43) and 56 nonculprit plaques (ACS n = 28, non-ACS n = 28) were analyzed using Virtual Histology intravascular ultrasound to examine relations among plasma hs-CRP, adiponectin, and ratios of each coronary plaque component. Plasma adiponectin was significantly lower and plasma hs-CRP was significantly higher in patients with than without ACS. Culprit plaques in patients with ACS had greater amounts of necrotic core plaque than those in patients without ACS. There was an inverse relation between serum hs-CRP and adiponectin with regard to necrotic core ratio in both culprit and nonculprit lesions in patients with ACS, but not those without ACS. In conclusion, increased plasma hs-CRP and hypoadiponectinemia might be related to the progression of ACS. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：1 / 7

页数：7

共 27 条

[1] Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].

Arita, Y ;

Kihara, S ;

Ouchi, N ;

Takahashi, M ;

Maeda, K ;

Miyagawa, J ;

Hotta, K ;

Shimomura, I ;

Nakamura, T ;

Miyaoka, K ;

Kuriyama, H ;

Nishida, M ;

Yamashita, S ;

Okubo, K ;

Matsubara, K ;

Muraguchi, M ;

Ohmoto, Y ;

Funahashi, T ;

Matsuzawa, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83

[2] Association between adiponectin and mediators of inflammation in obese women [J].

Engeli, S ;

Feldpausch, M ;

Gorzelniak, K ;

Hartwig, F ;

Heintze, U ;

Janke, J ;

Möhlig, M ;

Pfeiffer, AFH ;

Luft, FC ;

Sharma, AM .

DIABETES, 2003, 52 (04) :942-947

[3] CAAS-II - A 2ND GENERATION SYSTEM FOR OFF-LINE AND ONLINE QUANTITATIVE CORONARY ANGIOGRAPHY [J].

GRONENSCHILD, E ;

JANSSEN, J ;

TIJDENS, F .

CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS, 1994, 33 (01) :61-75

[4] Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients [J].

Hotta, K ;

Funahashi, T ;

Arita, Y ;

Takahashi, M ;

Matsuda, M ;

Okamoto, Y ;

Iwahashi, H ;

Kuriyama, H ;

Ouchi, N ;

Maeda, K ;

Nishida, M ;

Kihara, S ;

Sakai, N ;

Nakajima, T ;

Hasegawa, K ;

Muraguchi, M ;

Ohmoto, Y ;

Nakamura, T ;

Yamashita, S ;

Hanafusa, T ;

Matsuzawa, Y .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (06) :1595-1599

[5] Possible contribution of C-reactive protein within coronary plaque to increasing its own plasma levels across coronary circulation [J].

Ishikawa, T ;

Imamura, T ;

Hatakeyama, K ;

Date, H ;

Nagoshi, T ;

Kawamoto, R ;

Matsuyama, A ;

Asada, Y ;

Eto, T .

AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (05) :611-614

[6] Involvement of C-reactive protein obtained by directional coronary atherectomy in plaque instability and developing restenosis in patients with stable or unstable angina pectoris [J].

Ishikawa, T ;

Hatakeyama, K ;

Imamura, T ;

Date, H ;

Shibata, Y ;

Hikichi, Y ;

Asada, Y ;

Eto, T .

AMERICAN JOURNAL OF CARDIOLOGY, 2003, 91 (03) :287-292

[7]

Katritsis D, 2001, CLIN CHEM, V47, P882

[8] Interaction of oxidative stress and inflammatory response in coronary plaque instability - Important role of C-reactive protein [J].

Kobayashi, S ;

Inoue, N ;

Ohashi, Y ;

Terashima, M ;

Matsui, K ;

Mori, T ;

Fujita, H ;

Awano, K ;

Kobayashi, K ;

Azumi, H ;

Ejiri, J ;

Hirata, K ;

Kawashima, S ;

Hayashi, Y ;

Yokozaki, H ;

Itoh, H ;

Yokoyama, M .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (08) :1398-1404

[9] Molecular mechanism of Metabolic Syndrome X: Contribution of adipocytokines adipocyte-derived bioactive substances [J].

Matsuzawa, Y ;

Funahashi, T ;

Nakamura, T .

THE METABOLIC SYNDROME X: CONVERGENCE OF INSULIN RESISTANCE, GLUCOSE INTOLERANCE, HYPERTENSION, OBESITY, AND DYSLIPIDEMIAS-SEARCHING FOR THE UNDERLYING DEFECTS, 1999, 892 :146-154

[10] HOMEOSTASIS MODEL ASSESSMENT - INSULIN RESISTANCE AND BETA-CELL FUNCTION FROM FASTING PLASMA-GLUCOSE AND INSULIN CONCENTRATIONS IN MAN [J].

MATTHEWS, DR ;

HOSKER, JP ;

RUDENSKI, AS ;

NAYLOR, BA ;

TREACHER, DF ;

TURNER, RC .

DIABETOLOGIA, 1985, 28 (07) :412-419

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