Rasistion- and obasky-associated metabolic diseases

被引：149

作者：

Lazar, M. A. ^{[1
]}

机构：

[1] Hosp Univ Penn, Sch Med, Inst Diabet Obes & Metab, Dept Med,Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA

来源：

HORMONE AND METABOLIC RESEARCH | 2007年 / 39卷 / 10期

关键词：

obesity; insulin resistance; resistin; adipokine;

D O I：

10.1055/s-2007-985897

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The link between obesity and diabetes is strong as well as complex. Fat cells produce many circulating regulators of insulin sensitivity, including pro-inflammatory cytokines. In rodents, resistin is produced by adipose tissue, and is a significant regulator of glucose metabolism and insulin sensitivity. In humans, resistin is derived made mainly from macrophages. Given the emerging interrelationship between inflammation and metabolic disease, hyperresistinemia may be a biomarker, and/or a mediator, of metabolic and inflammatory diseases in humans as well as in rodents.

引用

页码：710 / 716

页数：7

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