Clinical features and outcome of community-onset bloodstream infections caused by extended-spectrum β-lactamase-producing Escherichia coli

被引：45

作者：

Kang, C. -I.

Cheong, H. S.

Chung, D. R.

Peck, K. R.

Song, J. -H.

Oh, M. -D.

Choe, K. -W.

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis, Seoul 135710, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2008年 / 27卷 / 01期

关键词：

D O I：

10.1007/s10096-007-0401-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study was conducted to evaluate the epidemiology and clinical features of bloodstream infections caused by extended-spectrum beta-lactamase-producing E. coli (ESBL-EC) in community-onset bacteremia. Of 929 episodes of community-onset E. coli bacteremia, 4.1% (38/929) had bacteremia with ESBL producers. Of these, 63.2% (24/38) were further classified as healthcare-associated infections. Although most patients had risk factors for infection due to ESBL producers, three patients with urinary tract infection, four patients with cholangitis, and one patient with a liver abscess had no identified predisposing risk factors. The 30-day mortality was 21.1% (8/38). ESBL-EC is a significant cause of bloodstream infection, even in patients with community-onset infection.

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页码：85 / 88

页数：4

相关论文

共 12 条

[1]

Bush K, 2001, CLIN INFECT DIS, V32, P1085, DOI 10.1086/319610

[2] The changing epidemiology of Staphylococcus aureus? [J].

Chambers, HF .

EMERGING INFECTIOUS DISEASES, 2001, 7 (02) :178-182

[3] Risk factors for the development of extended-spectrum beta-lactamase-producing bacteria in nonhospitalized patients [J].

Colodner, R ;

Rock, W ;

Chazan, B ;

Keller, N ;

Guy, N ;

Sakran, W ;

Raz, R .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2004, 23 (03) :163-167

[4] Health care-associated bloodstream infections in adults: A reason to change the accepted definition of community-acquired infections [J].

Friedman, ND ;

Kaye, KS ;

Stout, JE ;

McGarry, SA ;

Trivette, SL ;

Briggs, JP ;

Lamm, W ;

Clark, C ;

MacFarquhar, J ;

Walton, AL ;

Reller, LB ;

Sexton, DJ .

ANNALS OF INTERNAL MEDICINE, 2002, 137 (10) :791-797

[5] Bloodstream infections due to extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae:: Risk factors for mortality and treatment outcome, with special emphasis on antimicrobial therapy [J].

Kang, CI ;

Kim, SH ;

Park, WB ;

Lee, KD ;

Kim, HB ;

Kim, EC ;

Oh, MD ;

Choe, KW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (12) :4574-4581

[6]

Mirelis B, 2003, EMERG INFECT DIS, V9, P1024

[7] Extended-spectrum β-lactamases:: a clinical update [J].

Paterson, DL ;

Bonomo, RA .

CLINICAL MICROBIOLOGY REVIEWS, 2005, 18 (04) :657-+

[8] Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum β-lactamases:: Implications for the clinical microbiology laboratory [J].

Paterson, DL ;

Ko, WC ;

Von Gottberg, A ;

Casellas, JM ;

Mulazimoglu, L ;

Klugman, KP ;

Bonomo, RA ;

Rice, LB ;

McCormack, JG ;

Yu, VL .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (06) :2206-2212

[9] Risk of resistance related to antibiotic use before admission in patients with community-acquired bacteraemia [J].

Pedersen, G ;

Schonheyder, HC ;

Steffensen, FH ;

Sorensen, HT .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1999, 43 (01) :119-126

[10] Epidemiology and clinical features of infections caused by extended-spectrum beta-lactamase-producing Escherichia coli in nonhospitalized patients [J].

Rodríguez-Baño, J ;

Navarro, MD ;

Romero, L ;

Martínez-Martínez, L ;

Muniain, MA ;

Perea, EJ ;

Pérez-Cano, R ;

Pascual, A .

JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (03) :1089-1094