HLA-DRB1, -DQB1 and -DPB1 polymorphism in the Slovak population

被引：19

作者：

Cechová, E

Fazekasová, H

Ferencík, S

Shawkatová, I

Buc, M

机构：

[1] Comenius Univ, Dept Immunol, Fac Med, Bratislava 81108, Slovakia

[2] Univ Hosp, Inst Immunol, Essen, Germany

来源：

TISSUE ANTIGENS | 1998年 / 51卷 / 05期

关键词：

HLA class II genotyping; PCR-RFLP; PCR-SSP; Slovak population;

D O I：

10.1111/j.1399-0039.1998.tb02996.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HLA-DRB1, -DQB1 and -DPB1 allele frequencies were investigated in a sample of the Slovak population by PCR-SSP and PCR-RFLP methods. The most frequent DRB1 alleles were DRB1*1101-5 (0.2038), DRB1*0701-2 (0.1423), and DRB1*1501-2 (0.1231). The most rare alleles found were DRB1*0901 (0.0038), and DRB1*1201 (0.015). The most common DQB1 alleles were DQB1*0301 (0.2448), DQB1*0201 (0.2098), and DQB1*0501 (0.1119), respectively. The alleles with the least occurrence rate were DQB1*0601 (0.0035) and DQBI*0401 (0.007). The most common DPB1 alleles found were DPB1*0401 (0.4329), DPB1*0402 (0.2089), and DPB1*0201 (0.1438), respectively. The least frequent alleles were DPB1*0601, *1101, and *1501 (0.0034). Allele frequencies found in our study were compared to those in Czech, Austrian, and German populations. No statistically significant differences were observed.

引用

页码：574 / 576

页数：3

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