Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae

被引：741

作者：

Jiao, Guangling ^{[1
,2
]}

Yu, Guangli ^{[2
]}

Zhang, Junzeng ^{[3
]}

Ewart, H. Stephen ^{[1
]}

机构：

[1] Natl Res Council Canada, Inst Marine Biosci, Halifax, NS B3H 3Z1, Canada

[2] Ocean Univ China, Key Lab Marine Drugs, Minist Educ, Sch Med & Pharm, Qingdao 266003, Shandong, Peoples R China

[3] Natl Res Council Canada, Inst Nutrisci & Hlth, Charlottetown, PE C1A 4P3, Canada

来源：

MARINE DRUGS | 2011年 / 9卷 / 02期

关键词：

sulfated polysaccharide; marine macroalgae; carbohydrate structure; bioactivity; oligosaccharides; MILD ACID-HYDROLYSIS; MOLECULAR-WEIGHT FUCOIDAN; CELL-WALL POLYSACCHARIDES; SEAWEED ECKLONIA-KUROME; BROWN SEAWEED; ANTICOAGULANT ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; DENGUE VIRUS; GREEN-ALGA;

D O I：

10.3390/md9020196

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sulfated polysaccharides and their lower molecular weight oligosaccharide derivatives from marine macroalgae have been shown to possess a variety of biological activities. The present paper will review the recent progress in research on the structural chemistry and the bioactivities of these marine algal biomaterials. In particular, it will provide an update on the structural chemistry of the major sulfated polysaccharides synthesized by seaweeds including the galactans (e.g., agarans and carrageenans), ulvans, and fucans. It will then review the recent findings on the anticoagulant/antithrombotic, antiviral, immuno-inflammatory, antilipidemic and antioxidant activities of sulfated polysaccharides and their potential for therapeutic application.

引用

页码：196 / 223

页数：28

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