Ceftazidime kinetics of diffusion in inoculated agar plates

被引：3

作者：

Arcelloni, C

Paroni, R

Basile, M

Bonini, PA

Vaiani, R

机构：

[1] HOSP SAN RAFFAELE,LAB CHROMATOG & SEPARAT TECH,I-20132 MILAN,ITALY

[2] HOSP SAN RAFFAELE,MICROBIOL SERV,I-20132 MILAN,ITALY

[3] HOSP SAN RAFFAELE,DEPT LAB MED,I-20132 MILAN,ITALY

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 05期

关键词：

D O I：

10.1128/AAC.40.5.1280

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ceftazidime concentration in agar plates inoculated with Pseudomonas aeruginosa was determined by high-performance liquid chromatography at fixed points (3, 6, 9, 12, and 15 mm) from the disk center and at fixed times (2, 4, 6, 16, and 24 h) to study the antibiotic kinetics of diffusion. A statistical difference between the concentrations determined in the presence of microorganisms and in uninoculated plates after 16 and 24 h was evidenced and was probably ascribable to the drug hydrolysis carried out by the induced beta-lactamase.

引用

页码：1280 / 1281

页数：2