Role of Plk2 (Snk) in mouse development and cell proliferation

被引：137

作者：

Ma, S

Charron, J

Erikson, RL

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Univ Laval, CHUQ, Hotel Dieu, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada

来源：

MOLECULAR AND CELLULAR BIOLOGY | 2003年 / 23卷 / 19期

关键词：

D O I：

10.1128/MCB.23.19.6936-6943.2003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plk2 (Snk) is a polo-like kinase expressed at G, in cultured cells and mainly in the hippocampal neurons in the brains of adult rodents, but its function is poorly understood. We have generated mice deficient in Plk2 by gene targeting. Although Plk2 is not required for postnatal growth, Plk2(-/-) embryos show retarded growth and skeletal development late in gestation. The labyrinthine zone of the placenta is diminished in Plk2(-/-) embryos due to decreased cell proliferation. Cultured Plk2(-/-) embryonic fibroblasts grow more slowly than normal cells and show delayed entry into S phase. These data suggest a role for Plk2 in the cell cycle.

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页码：6936 / 6943

页数：8

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