The Evolving War on Cancer

被引：176

作者：

Haber, Daniel A. ^{[1
,4
]}

Gray, Nathanael S. ^{[2
,3
]}

Baselga, Jose ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[4] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

CELL | 2011年 / 145卷 / 01期

关键词：

CELL LUNG-CANCER; KINASE INHIBITORS; MUTATIONS; EGFR; GEFITINIB; IMATINIB; GENE; IDENTIFICATION; CHROMOSOME; RESISTANCE;

D O I：

10.1016/j.cell.2011.03.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Building on years of basic scientific discovery, recent advances in the fields of cancer genetics and medicinal chemistry are now converging to revolutionize the treatment of cancer. Starting with serendipitous observations in rare subsets of cancer, a paradigm shift in clinical research is poised to ensure that new molecular insights are rapidly applied to shape emerging cancer therapies. Could this mark a turning point in the "War on Cancer''?

引用

页码：19 / 24

页数：6

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