The biomarker landscape in mycosis fungoides and Sezary syndrome

被引：27

作者：

Dulmage, Brittany ^{[1
]}

Geskin, Larisa ^{[2
]}

Guitart, Joan ^{[3
]}

Akilov, Oleg E. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Dermatol, Pittsburgh, PA 15260 USA

[2] Columbia Univ, Dept Dermatol, New York, NY 10027 USA

[3] Northwestern Univ, Dept Dermatol, Chicago, IL 60611 USA

来源：

EXPERIMENTAL DERMATOLOGY | 2017年 / 26卷 / 08期

关键词：

cell surface marker; cutaneous T-cell lymphoma; gene expression; screening; secretory protein; T-CELL LYMPHOMA; TUMOR-ASSOCIATED ANTIGENS; PROGNOSTIC-FACTORS; MICRORNA EXPRESSION; GENE-EXPRESSION; PROGRAMMED DEATH-1; PERIPHERAL-BLOOD; FLOW-CYTOMETRY; CTCL PATIENTS; EUROPEAN-ORGANIZATION;

D O I：

10.1111/exd.13261

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

The practice of pre-emptive individualized medicine is predicated on the discovery, development and application of biomarkers in specific clinical settings. Mycosis fungoides and Sezary syndrome are the two most common type of cutaneous T-cell lymphoma, yet diagnosis, prognosis and disease monitoring remain a challenge. In this review, we discuss the current state of biomarker discovery in mycosis fungoides and Sezary syndrome, highlighting the most promising molecules in different compartments. Further, we emphasize the need for continued multicentre efforts to validate available and new biomarkers and to develop prospective combinatorial panels of already discovered molecules.

引用

页码：668 / 676

页数：9

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