Effect of melatonin and tetrapeptide on gene expression in mouse brain

被引：2

作者：

Anisimov, SV ^{[1
]}

Khavinson, VK

Anisimov, VN

机构：

[1] Lund Univ, Wallenberg Ctr Neurol, Lund, Sweden

[2] Russian Acad Sci, St Petersburg Inst Bioregulat & Gerontol, Northwestern Div, Moscow 117901, Russia

[3] Minist Publ Hlth Russia, NN Petrov Inst Oncol, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2004年 / 138卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

melatonin; peptide; Epithalon; gene expression; cDNA microchips;

D O I：

10.1007/s10517-005-0082-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A microchip technique was used to study expression of 16,897 clones from a cDNA library in the brain of mice receiving melatonin or tetrapeptide Epithalon (Ala-Glu-Asp-Gly). Expression of 53 transcripts in mouse brain underwent significant changes after treatment with the preparations. Melatonin and Epithalon modified expression of 38 and 22 transcripts, respectively. These preparations produced similar changes in the expression of 6 transcripts. Expression of 1 transcript (Rp119) was inhibited by melatonin, but induced by Epithalon. The target genes are physiologically related to the cell cycle, apoptosis, biosynthesis, processing, and transport of nucleic acids. Comparative study of gene expression in the brain and heart of CBA mice receiving melatonin and Epithalon suggest that these preparations have a tissue-specific biological effect.

引用

页码：504 / 509

页数：6

共 15 条

[1] Microarray technology in studying the effect of melatonin on gene expression in the mouse heart [J].