Asymmetric Diels-Alder reactions of 2-fluoroacrylic acid derivatives. Part 1: The construction of fluorine substituted chiral tertiary carbon

被引：34

作者：

Ito, H ^{[1
]}

Saito, A ^{[1
]}

Taguchi, T ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Tokyo 1920392, Japan

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(98)00195-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

For the construction of chiral monofluorinated tertiary carbons, we have examined the asymmetric Diels-Alder reaction of 2-fluoroacrylic acid derivatives bearing a chiral oxazolidinone moiety. Under diethylaluminum chloride catalyzed conditions at -100 degrees C, the reaction of 1 with isoprene proceeded smoothly with high diastereoselectivity. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：1979 / 1987

页数：9

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