Lower cortisol and higher ACTH levels in individuals with autism

被引：64

作者：

Curin, JM

Terzic, J

Petkovic, ZB

Zekan, L

Terzic, IM

Susnjara, IM

机构：

[1] Univ Split, Sch Med, Dept Physiol, Split, Croatia

[2] Ctr Autism, Zagreb, Croatia

[3] Clin Hosp, Dept Nucl Med, Split, Croatia

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2003年 / 33卷 / 04期

关键词：

autism; cortisol; ACTH;

D O I：

10.1023/A:1025019030121

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Blood concentrations of pituitary hormones adrenocorticotropin (ACTH), prolactin, growth hormone, and adrenal hormone-cortisol were measured in 36 autistic and 27 control individuals. Individuals with autism had significantly lower serum concentrations of cortisol (p < 10(-6)), and significantly higher concentrations of ACTH (p = 0.002) than control age- and sex-matched subjects. Also, prolactin concentrations in autistic patients with epilepsy were significantly higher when compared with normal subjects. The observed hormonal changes may indicate dysfunction of the hypothalamo-pituitary-adrenal axis in individuals with autism.

引用

页码：443 / 448

页数：6

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[1] IMPAIRED RECOGNITION OF EMOTION IN FACIAL EXPRESSIONS FOLLOWING BILATERAL DAMAGE TO THE HUMAN AMYGDALA [J].