The wide pharmacological versatility of semicarbazones, thiosemicarbazones and their metal complexes

被引：734

作者：

Beraldo, H ^{[1
]}

Gambino, D

机构：

[1] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Republica, Fac Quim, Dept Estrella Campos, Catedra Quim Inorgan, Montevideo, Uruguay

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2004年 / 4卷 / 01期

关键词：

semicarbazones; thiosemicarbazones; biological activity; pharmacological applications; bioactive metal complexes; mechanisms of action;

D O I：

10.2174/1389557043487484

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The more significant bioactivities of a variety of semicarbazones (anti-protozoa, anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and their metal complexes are reviewed together with proposed mechanisms of action and structure-activity relationships. Clinical or potential pharmacological applications of these versatile compounds are discussed.

引用

页码：31 / 39

页数：9

共 150 条

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