The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey

被引：62

作者：

Bocchetta, Martina ^{[1
]}

Galluzzi, Samantha ^{[1
,2
]}

Kehoe, Patrick Gavin ^{[3
]}

Aguera, Eduardo ^{[4
]}

Bernabei, Roberto ^{[5
]}

Bullock, Roger ^{[6
]}

Ceccaldi, Mathieu ^{[7
]}

Dartigues, Jean-Francois ^{[8
]}

de Mendonca, Alexandre ^{[9
]}

Didic, Mira ^{[7
]}

Eriksdotter, Maria ^{[10
]}

Felician, Olivier ^{[7
]}

Froelich, Lutz ^{[11
]}

Gertz, Hermann-Josef ^{[12
]}

Hallikainen, Merja ^{[13
]}

Hasselbalch, Steen G. ^{[14
]}

Hausner, Lucrezia ^{[11
]}

Heuser, Isabell ^{[15
]}

Jessen, Frank ^{[16
,17
]}

Jones, Roy W. ^{[18
]}

Kurz, Alexander ^{[19
]}

Lawlor, Brian ^{[20
]}

Lleo, Alberto ^{[21
]}

Martinez-Lage, Pablo ^{[22
]}

Mecocci, Patrizia ^{[23
]}

Mehrabian, Shima ^{[24
]}

Monsch, Andreas ^{[25
]}

Nobili, Flavio ^{[26
]}

Nordberg, Agneta ^{[6
]}

Rikkert, Marcel Olde ^{[27
]}

Orgogozo, Jean-Marc ^{[8
]}

Pasquier, Florence ^{[28
]}

Peters, Oliver ^{[29
]}

Salmon, Eric ^{[30
]}

Sanchez-Castellano, Carmen ^{[31
]}

Santana, Isabel ^{[32
]}

Sarazin, Marie ^{[33
]}

Traykov, Latchezar ^{[24
]}

Tsolaki, Magda ^{[34
]}

Visser, Pieter Jelle ^{[35
,36
]}

Wallin, Asa K. ^{[37
]}

Wilcock, Gordon ^{[38
]}

Wilkinson, David ^{[39
]}

Wolf, Henrike ^{[17
,40
]}

Yener, Goersev ^{[41
]}

Zekry, Dina ^{[42
,43
]}

Frisoni, Giovanni B. ^{[43
,44
]}

机构：

[1] IRCCS Ist Ctr S Giovanni di Dio Fatebenefratelli, LENITEM, Brescia, Italy

[2] Univ Brescia, Dept Mol & Translat Med, Brescia, Italy

[3] Univ Bristol, Frenchay Hosp, Sch Clin Sci, Dementia Res Grp, Bristol, Avon, England

[4] Hosp Univ Reina Sofia Cordoba, Serv Neurol, Cordoba, Spain

[5] Univ Cattolica Sacro Cuore, Dept Gerontol Geriatr & Psychiat Sci, Rome, Italy

[6] Victoria Ctr, Swindon, Wilts, England

[7] Aix Marseille Univ, CHU Timone, Serv Neurol & Neuropsychol, Marseille, France

[8] Bordeaux CMRR, Bordeaux, France

[9] Inst Mol Med, Lab Neurosci, Lisbon, Portugal

[10] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

[11] Heidelberg Univ, Gesundheit Mannheim, Zentralinst Seel, Dept Geriatr Psychiat, Mannheim, Germany

[12] Univ Hosp Leipzig, Dept Psychiat & Psychotherapy, Leipzig, Germany

[13] Kuopio Univ Hosp, Univ Eastern Finland, SF-70210 Kuopio, Finland

[14] Rigshosp, Memory Disorders Res Unit, DK-2100 Copenhagen, Denmark

[15] Univ Klinikum Bonn, Klin & Poliklin Psychiat & Psychotherapie, Bonn, Germany

[16] Univ Bonn, Dept Psychiat, Bonn, Germany

[17] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[18] Royal United Hosp, RICE Res Inst Care Older People, Bath BA1 3NG, Avon, England

[19] Tech Univ Munich, Psychiat Klin, D-80290 Munich, Germany

[20] St James Hosp, Mercers Inst Res Ageing, Dublin 8, Ireland

[21] Hosp Santa Creu & Sant Pau, Neurol Serv, Memory Unit, Barcelona, Spain

[22] Fdn CITA Alzheinzer Fundazioa, San Sebastian, Spain

[23] Univ Perugia, Sect Gerontol & Geriatr, I-06100 Perugia, Italy

[24] Univ Hosp Alexandrovska, Dept Neurol, Sofia, Bulgaria

[25] Univ Basel, Felix Platter Hosp, Univ Ctr Med Aging Basel, Memory Clin, Basel, Switzerland

[26] Univ Genoa, Dept Neurosci DINOGMI, Neurol Clin, Genoa, Italy

[27] Radboud Univ Nijmegen, Med Ctr, Radboud Alzheimer Ctr, Dept Geriatr Med, NL-6525 ED Nijmegen, Netherlands

[28] Univ Lille 2, CHU Lille, Lille, France

[29] Charite, Dept Psychiat, D-13353 Berlin, Germany

[30] Univ Liege, Cyclotron Res Ctr, Liege, Belgium

[31] Hosp Univ Ramon & Cajal, Serv Geriatria, Madrid, Spain

[32] Coimbra Univ Hosp, Dept Neurol, Coimbra, Portugal

[33] Univ Paris 05, Sorbonne Paris Cite, Ctr Hosp St Anne, INSERM UMR S894,Neurol Memoire & Langage, Paris, France

[34] Aristotle Univ Thessaloniki, Dept Neurol 3, GR-54006 Thessaloniki, Greece

[35] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands

[36] Maastricht Univ, Alzheimer Ctr, NL-6200 MD Maastricht, Netherlands

[37] Lund Univ, Memory Clin Maloma, Clin Memory Res Unit, S-22100 Lund, Sweden

[38] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Oxford OX3 9DU, England

[39] Moorgreen Hosp, MARC, Southampton, Hants, England

[40] Dept Psychiat Res, Zurich, Switzerland

[41] Dokuz Eylul Univ, Izmir, Turkey

[42] Univ Hosp Geneva, Dept Internal Med & Geriatr, Geneva, Switzerland

[43] Univ Geneva, Geneva, Switzerland

[44] Univ Hosp Geneva, Memory Clin, Geneva, Switzerland

来源：

ALZHEIMERS & DEMENTIA | 2015年 / 11卷 / 02期

关键词：

Biomarkers; Alzheimer's disease; Mild cognitive impairment; Diagnosis; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS ASSOCIATION WORKGROUPS; TEMPORAL-LOBE ATROPHY; CEREBROSPINAL-FLUID; NATIONAL INSTITUTE; VASCULAR DEMENTIA; VISUAL ASSESSMENT; CSF BIOMARKERS; F-18-FDG PET; DISEASE;

D O I：

10.1016/j.jalz.2014.06.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

We investigated the use of Alzheimer's disease (AD) biomarkers in European Alzheimer's Disease Consortium centers and assessed their perceived usefulness for the etiologic diagnosis of mild cognitive impairment (MCI). We surveyed availability, frequency of use, and confidence in diagnostic usefulness of markers of brain amyloidosis (amyloid position emission tomography [PET], cerebrospinal fluid [CSF] A beta 42) and neurodegeneration (medial temporal atrophy [MTA] on MR, fluorodeoxyglucose positron emission tomography [FDG-PET], CSF tau). The most frequently used biomarker is visually rated MTA (75% of the 37 responders reported using it "always/frequently") followed by CSF markers (22%), FDG-PET (16%), and amyloid-PET (3%). Only 45% of responders perceive MTA as contributing to diagnostic confidence, where the contribution was rated as "moderate". Seventy-nine percent of responders felt "very/extremely" comfortable delivering a diagnosis of MCI due to AD when both amyloid and neuronal injury biomarkers were abnormal (P < .02 versus any individual biomarker). Responders largely agreed that a combination of amyloidosis and neuronal injury biomarkers was a strongly indicative AD signature. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：195 / 206

页数：12

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