An efficient solid phase synthesis of 5′-phosphodiester and phosphoramidate monoester nucleoside analogues

被引：8

作者：

De Napoli, L ^{[1
]}

Di Fabio, G ^{[1
]}

D'Onofrio, J ^{[1
]}

Montesarchio, D ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Chim Organ & Biochim, I-80126 Naples, Italy

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 20期

关键词：

D O I：

10.1039/b501043h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An easy and efficient strategy to obtain libraries of 5'-phosphodiester and 5'-phosphoramidate monoester nucleoside analogues in a highly pure form has been developed, starting from a new nucleoside based solid support. The nucleoside scaffold has been anchored through a 5'-phosphodiester linkage to Tentagel(R) HL resin, functionalized with a 3-chloro-4-hydroxyphenylacetic linker. The solid phase synthesis of small libraries of 5'-phosphodiester and 5'-phosphoramidate monoester thymidine analogues is also reported.

引用

页码：2586 / 2588

页数：3

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