Sophistication of foldamer form and function in vitro and in vivo

被引：127

作者：

Bautista, Arjel D. ^{[1
]}

Craig, Cody J. ^{[1
]}

Harker, Elizabeth A. ^{[1
]}

Schepartz, Alanna ^{[1
,2
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2007年 / 11卷 / 06期

关键词：

D O I：

10.1016/j.cbpa.2007.09.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Advances in the foldamer field in recent years areas diverse as the backbones of which they are composed. Applications have ranged from cellular penetration and membrane disruption to discrete molecular recognition, while efforts to control the complex geometric shape of foldamers has entered the realm of tertiary and quaternary structure. This review will provide recent examples of progress in the foldamer field, highlighting the significance of this class of compounds and the advances that have been made towards exploiting their full potential.

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页码：685 / 692

页数：8

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