Fibroblast growth factor (FGF)23 in patients with acromegaly

被引：28

作者：

Ito, Nobuaki ^{[2
]}

Fukumoto, Seji ^{[2
]}

Taguchi, Manabu ^{[1
]}

Takeshita, Akira ^{[1
,2
]}

Takeuchi, Yasuhiro ^{[1
]}

Yamada, Shozo ^{[1
]}

Fujita, Toshiro ^{[2
]}

机构：

[1] Toranomon Gen Hosp, Ctr Endocrine, Tokyo 1058470, Japan

[2] Tokyo Univ Hosp, Dept Med, Div Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan

来源：

ENDOCRINE JOURNAL | 2007年 / 54卷 / 03期

关键词：

FGF23; acromegaly; hyperphosphatemia; GH; IGF-1;

D O I：

10.1507/endocrj.K06-217

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fibroblast growth factor (FGF)23 is a hormone that regulates serum phosphate and 1,25-dihydroxyvitamin D levels. Hyperphosphatemia is sometimes observed in patients with acromegaly while the detailed mechanism of this abnormal phosphate metabolism remains to be elucidated. We have measured FGF23 levels in 18 patients before and after the surgery for acromegaly. Serum GH, IGF-I and phosphate significantly decreased after the surgery. In addition, FGF23 also reduced by the Surgery. These results indicate that deficient action of FGF23 is not the cause of deranged phosphate metabolism in patients with acromegaly.

引用

页码：481 / 484

页数：4

共 21 条

[1] A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis [J].

Araya, K ;

Fukumoto, S ;

Backenroth, R ;

Takeuchi, Y ;

Nakayama, K ;

Ito, N ;

Yoshii, N ;

Yamazaki, Y ;

Yamashita, T ;

Silver, J ;

Igarashi, T ;

Fujita, T .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (10) :5523-5527

[2] Effects of short-term insulin-like growth factor-I or growth hormone treatment on bone turnover, renal phosphate reabsorption and 1,25 dihydroxyvitamin D-3 production in healthy man [J].

Bianda, T ;

Hussain, MA ;

Glatz, Y ;

Bouillon, R ;

Froesch, ER ;

Schmid, C .

JOURNAL OF INTERNAL MEDICINE, 1997, 241 (02) :143-150

[3]

BIJVOET OLM, 1970, LANCET, V1, P1345

[4] Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism [J].

Feng, Jian Q. ;

Ward, Leanne M. ;

Liu, Shiguang ;

Lu, Yongbo ;

Xie, Yixia ;

Yuan, Baozhi ;

Yu, Xijie ;

Rauch, Frank ;

Davis, Siobhan I. ;

Zhang, Shubin ;

Rios, Hector ;

Drezner, Marc K. ;

Quarles, L. Darryl ;

Bonewald, Lynda F. ;

White, Kenneth E. .

NATURE GENETICS, 2006, 38 (11) :1310-1315

[5] Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men [J].

Ferrari, SL ;

Bonjour, JP ;

Rizzoli, R .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (03) :1519-1524

[6] FGF-23 is elevated by chronic hyperphosphatemia [J].

Gupta, A ;

Winer, K ;

Econs, MJ ;

Marx, SJ ;

Collins, MT .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (09) :4489-4492

[7] EFFECTS OF INSULIN-LIKE GROWTH FACTOR-I ON RENAL-FUNCTION IN NORMAL MEN [J].

HIRSCHBERG, R ;

BRUNORI, G ;

KOPPLE, JD ;

GULER, HP .

KIDNEY INTERNATIONAL, 1993, 43 (02) :387-397

[8] FGF-23 in patients with end-stage renal disease on hemodialysis [J].

Imanishi, Y ;

Inaba, M ;

Nakatsuka, K ;

Nagasue, K ;

Okuno, S ;

Yoshihara, A ;

Miura, M ;

Miyauchi, A ;

Kobayashi, K ;

Miki, T ;

Shoji, T ;

Ishimura, E ;

Nishizawa, Y .

KIDNEY INTERNATIONAL, 2004, 65 (05) :1943-1946

[9] Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. [J].

Jonsson, KB ;

Zahradnik, R ;

Larsson, T ;

White, KE ;

Sugimoto, T ;

Imanishi, Y ;

Yamamoto, T ;

Hampson, G ;

Koshiyama, H ;

Ljunggren, Ö ;

Oba, K ;

Yang, IM ;

Miyauchi, A ;

Econs, MJ ;

Lavigne, J ;

Jüppner, H .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (17) :1656-1663

[10] A novel recessive mutation in fibroblast growth factor-23 causes familial tumoral calcinosis [J].

Larsson, T ;

Yu, XJ ;

Davis, SI ;

Draman, MS ;

Mooney, SD ;

Cullen, MJ ;

White, KE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (04) :2424-2427

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