Insulin-like growth factor-I receptors and estrogen receptors interact in the promotion of neuronal survival and neuroprotection

被引：83

作者：

Garcia-Segura, LM ^{[1
]}

Cardona-Gómez, GP

Chowen, LA

Azcoitia, I

机构：

[1] CSIC, Inst Cajal, E-28002 Madrid, Spain

[2] Hosp Nino Jesus, Unidad Invest, E-28009 Madrid, Spain

[3] Univ Complutense Madrid, Fac Biol, Dept Biol Celular, E-28040 Madrid, Spain

来源：

JOURNAL OF NEUROCYTOLOGY | 2000年 / 29卷 / 5-6期

关键词：

D O I：

10.1023/A:1007125626308

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Several in vitro and in vivo studies have shown that estrogen has neuroprotective properties. The neuroprotective effects of estrogen are probably exerted through several mechanisms, it is established that estrogen can provide neuroprotection by actions that are independent of estrogen receptor activation. In addition, in several experimental models, activation of estrogen receptors appears to be indispensable for neuroprotection. This review focuses on neuroprotection mediated by estrogen receptors. The interaction of estrogen with growth factor receptor signaling to induce neuroprotection is discussed. Evidence is presented that estrogen receptors and insulin-like growth factor-I receptors interact in the promotion of neuronal survival and neuroprotection.

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页码：425 / 437

页数：13

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