Highly enantioselective Friedel-Crafts alkylations of pyrroles and indoles with α-hydroxy enones under Cu(II)-simple bis(oxazoline) catalysis

被引：211

作者：

Palomo, C ^{[1
]}

Oiarbide, M ^{[1
]}

Kardak, BG ^{[1
]}

García, JM ^{[1
]}

Linden, A ^{[1
]}

机构：

[1] Univ Basque Country, Fac Quim, Dept Quim Organ 1, E-20080 San Sebastian, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 12期

关键词：

D O I：

10.1021/ja0423217

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Remarkably high and regular enantioselectivities are obtained in Friedel-Crafts alkylation reactions involving α-hydroxy enone templates and Cu(II)-bis(oxazoline) complexes as catalysts. The simple elaboration of adducts provides a route to enantioenriched aldehydes, carboxylic acids, and ketones containing the pyrrole and indole frameworks. Copyright © 2005 American Chemical Society.

引用

页码：4154 / 4155

页数：2

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