Cellular sources and immune functions of interleukin-9

被引：237

作者：

Noelle, Randolph J. ^{[1
,2
,3
]}

Nowak, Elizabeth C. ^{[1
,2
]}

机构：

[1] Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

[2] Norris Cotton Canc Ctr, Lebanon, NH 03756 USA

[3] Kings Coll London, Guys Hosp, Med Res Council MRC Ctr Transplantat, London SE1 9RT, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 10期

基金：

英国医学研究理事会;

关键词：

INTERFERON-REGULATORY FACTOR-4; T-CELLS; TGF-BETA; IL-9; PRODUCTION; MAST-CELLS; OXIDATIVE BURST; STAT ACTIVATION; WORM EXPULSION; UP-REGULATION; EXPRESSION;

D O I：

10.1038/nri2848

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-9 (IL-9) has attracted renewed interest owing to the identification of its expression by multiple T helper (T(H)) cell subsets, including T(H)2 cells, T(H)9 cells, T(H)17 cells and regulatory T (T(Reg)) cells. Here, we provide a broad overview of the conditions that are required for cells to produce IL-9 and describe the cellular targets and nature of the immune responses that are induced by IL-9.

引用

页码：683 / 687

页数：5

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