Role of the satiety factor oleoylethanolamide in alcoholism

被引：58

作者：

Bilbao, Ainhoa ^{[1
,2
]}

Serrano, Antonia ^{[1
,3
]}

Cippitelli, Andrea ^{[5
]}

Pavon, Francisco J. ^{[1
,3
]}

Giuffrida, Andrea ^{[6
]}

Suarez, Juan ^{[1
]}

Garcia-Marchena, Nuria ^{[1
,7
]}

Baixeras, Elena ^{[1
]}

Gomez de Heras, Raquel ^{[7
]}

Orio, Laura ^{[7
]}

Alen, Francisco ^{[7
]}

Ciccocioppo, Roberto ^{[5
]}

Cravatt, Benjamin F. ^{[4
]}

Parsons, Loren H. ^{[3
]}

Piomelli, Daniele ^{[8
,9
,10
,11
]}

Rodriguez de Fonseca, Fernando ^{[1
,7
]}

机构：

[1] Hosp Reg Univ Malaga, Inst IBIMA, Unidad Gest Clin Salud Mental, Malaga, Spain

[2] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Inst Psychopharmacol, Heidelberg, Germany

[3] Scripps Res Inst, Comm Neurobiol Addict Disorders, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Dept Chem Physiol, La Jolla, CA 92037 USA

[5] Univ Camerino, Pharmacol Unit, Sch Pharm, I-62032 Camerino, Italy

[6] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA

[7] Univ Complutense Madrid, Fac Psicol, Dept Psicobiol, E-28040 Madrid, Spain

[8] Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92717 USA

[9] Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA

[10] Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92717 USA

[11] Ist Italiano Tecnol, Dept Drug Discovery & Dev, Genoa, Italy

来源：

ADDICTION BIOLOGY | 2016年 / 21卷 / 04期

关键词：

Alcohol self-administration; alcoholism; oleoylethanolamide; PPAR-alpha; relapse; CANNABINOID CB1 RECEPTOR; ENDOCANNABINOID SYSTEM; NUCLEUS-ACCUMBENS; DIETARY-FAT; RAT; ETHANOL; ACTIVATION; PHYSIOLOGY; EXPOSURE; RELEASE;

D O I：

10.1111/adb.12276

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Oleoylethanolamide (OEA) is a satiety factor that controls motivational responses to dietary fat. Here we show that alcohol administration causes the release of OEA in rodents, which in turn reduces alcohol consumption by engaging peroxisome proliferator-activated receptor-alpha (PPAR-). This effect appears to rely on peripheral signaling mechanisms as alcohol self-administration is unaltered by intracerebral PPAR- agonist administration, and the lesion of sensory afferent fibers (by capsaicin) abrogates the effect of systemically administered OEA on alcohol intake. Additionally, OEA is shown to block cue-induced reinstatement of alcohol-seeking behavior (an animal model of relapse) and reduce the severity of somatic withdrawal symptoms in alcohol-dependent animals. Collectively, these findings demonstrate a homeostatic role for OEA signaling in the behavioral effects of alcohol exposure and highlight OEA as a novel therapeutic target for alcohol use disorders and alcoholism.

引用

页码：859 / 872

页数：14

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