Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells

被引：9

作者：

Tang, Yue ^{[1
,2
]}

Abe, Naomi ^{[1
]}

Yoshimoto, Motoko ^{[1
]}

Zhu, Beiwei ^{[2
]}

Murata, Yoshiyuki ^{[1
]}

Nakamura, Yoshimasa ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Environm & Life Sci, Okayama 7008530, Japan

[2] Dalian Polytech Univ, Sch Food Sci & Technol, Dalian, Peoples R China

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2015年 / 79卷 / 01期

关键词：

mitogen-activated protein kinase (MAPK); nuclear factor-kappa B (NF-kappa B); interleukin-13(IL-13); benzyl isothiocyanate; nuclear factor of activated T cells c1(NFATc1); ACTIVATED HUMAN BASOPHILS; KAPPA-B; ALLERGIC DISEASE; RECEPTOR; INTERLEUKIN-4; INFLAMMATION; FISETIN; PATHWAY; ASTHMA;

D O I：

10.1080/09168451.2014.963503

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium ionophore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogen-activated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.

引用

收藏

页码：159 / 163

页数：5

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