Sterol metabolism and SREBP activation

被引：266

作者：

Sato, Ryuichiro ^{[1
]}

机构：

[1] Univ Tokyo, Dept Appl Biol Chem, Grad Sch Agr & Life Sci, Tokyo 1138657, Japan

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2010年 / 501卷 / 02期

关键词：

Sterol metabolism; SREBP; HMG CoA reductase; SCAP; Insig; ABCA1; TRC8; ELEMENT-BINDING PROTEIN-1; HMG-COA REDUCTASE; HIGH-DENSITY-LIPOPROTEINS; FATTY-ACID SYNTHESIS; ENDOPLASMIC-RETICULUM; CHOLESTEROL-SYNTHESIS; HEPATIC ABCA1; INTRAMEMBRANE CLEAVAGE; TRANSCRIPTION FACTOR; MICE;

D O I：

10.1016/j.abb.2010.06.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cholesterol is one of the major components of membrane lipids Adjustment of the membrane cholesterol balance is. therefore, pivotal in the maintenance of cellular homeostasis Cholesterol biosynthesis and uptake are tightly regulated at the transcriptional level through a negative feedback control. The transcription factor family known as sterol regulatory element-binding proteins (SREBPs) is in charge of this feedback control In particular, SREBP-2 is activated in a cholesterol-dependent manner, and hence is deeply involved in regulation of the expression of genes closely related to cholesterol metabolism Sterol metabolites, including cholesterol, 24.25-dihydrolanosterol and oxysterols, strongly participate in the regulation of sterol metabolism via binding to its particular proteins. (C) Elsevier Inc All rights reserved

引用

页码：177 / 181

页数：5

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