Effects of interleukin-6 produced in coronary circulation on production of C-reactive protein and coronary microvascular resistance

被引：11

作者：

Date, H ^{[1
]}

Imamura, T ^{[1
]}

Sumi, T ^{[1
]}

Ishikawa, T ^{[1
]}

Kawagoe, J ^{[1
]}

Onitsuka, H ^{[1
]}

Kawamoto, R ^{[1
]}

Nagoshi, T ^{[1
]}

Eto, T ^{[1
]}

机构：

[1] Miyazaki Univ, Miyazaki Med Coll, Dept Internal Med, Miyazaki 88916, Japan

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2005年 / 95卷 / 07期

关键词：

D O I：

10.1016/j.amjcard.2004.11.049

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We measured plasma levels of interleukin-6 and C-reactive protein at the orifice of the left coronary artery and at the great cardiac vein in patients who had coronary artery disease and those who had angiographically normal coronary arteries (controls). We also measured coronary microvascular resistance in the control group. We found increased levels of interleukin-6 in the coronary circulation of patients who had coronary artery disease compared with controls. This increase correlated with C-reactive protein production in the coronary circulation and coronary microvascular resistance. These findings suggest that a localized cytokine/inflammatory pathway functions in the coronary circulation and that interleukin-6 is involved in modulating coronary vascular tone. (c) 2005 by Excerpta Medica Inc.

引用

页码：849 / 852

页数：4

共 19 条

[1]

Diastolic fractional flow reserve to assess the functional severity of moderate coronary artery stenoses - Comparison with fractional flow reserve and coronary flow velocity reserve [J].

Abe, M ;

Tomiyama, H ;

Yoshida, H ;

Doba, N .

CIRCULATION, 2000, 102 (19) :2365-2370

[2]

Elevated levels of interleukin-6 in unstable angina [J].

Biasucci, LM ;

Vitelli, A ;

Liuzzo, G ;

Altamura, S ;

Caligiuri, G ;

Monaco, C ;

Rebuzzi, AG ;

Ciliberto, G ;

Maseri, A .

CIRCULATION, 1996, 94 (05) :874-877

[3]

Sites of interleukin-16 release in patients with acute coronary syndromes and in patients with congestive heart failure [J].

Deliargyris, EN ;

Raymond, RJ ;

Theoharides, TC ;

Boucher, WS ;

Tate, DA ;

Dehmer, GJ .

AMERICAN JOURNAL OF CARDIOLOGY, 2000, 86 (09) :913-918

[4]

INTERLEUKIN-6 AND THE ACUTE PHASE RESPONSE [J].

HEINRICH, PC ;

CASTELL, JV ;

ANDUS, T .

BIOCHEMICAL JOURNAL, 1990, 265 (03) :621-636

[5]

Interleukin-6 and acute coronary syndrome [J].

Ikeda, U ;

Ito, T ;

Shimada, K .

CLINICAL CARDIOLOGY, 2001, 24 (11) :701-704

[6]

Possible contribution of C-reactive protein within coronary plaque to increasing its own plasma levels across coronary circulation [J].

Ishikawa, T ;

Imamura, T ;

Hatakeyama, K ;

Date, H ;

Nagoshi, T ;

Kawamoto, R ;

Matsuyama, A ;

Asada, Y ;

Eto, T .

AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (05) :611-614

[7]

Involvement of C-reactive protein obtained by directional coronary atherectomy in plaque instability and developing restenosis in patients with stable or unstable angina pectoris [J].

Ishikawa, T ;

Hatakeyama, K ;

Imamura, T ;

Date, H ;

Shibata, Y ;

Hikichi, Y ;

Asada, Y ;

Eto, T .

AMERICAN JOURNAL OF CARDIOLOGY, 2003, 91 (03) :287-292

[8]

Angiostatin - A negative regulator of endothelial-dependent vasodilation [J].

Koshida, R ;

Ou, JS ;

Matsunaga, T ;

Chilian, WM ;

Oldham, KT ;

Ackerman, AW ;

Pritchard, KA .

CIRCULATION, 2003, 107 (06) :803-806

[9]

Relationship between interleukin-6 production in the lungs and pulmonary vascular resistance in patients with congestive heart failure [J].

Mabuchi, N ;

Tsutamoto, T ;

Wada, A ;

Ohnishi, M ;

Maeda, K ;

Hayashi, M ;

Kinoshita, M .

CHEST, 2002, 121 (04) :1195-1202

[10]

Meuwissen M, 2001, CIRCULATION, V103, P184

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