Defective lymphotoxin-β receptor-induced NF-κB transcriptional activity in NIK-deficient mice

被引：343

作者：

Yin, L

Wu, L

Wesche, H

Arthur, CD

White, JM

Goeddel, DV

Schreiber, RD ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, Ctr Immunol, St Louis, MO 63110 USA

[2] Tularik Inc, S San Francisco, CA 94080 USA

来源：

SCIENCE | 2001年 / 291卷 / 5511期

关键词：

D O I：

10.1126/science.1058453

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The role of NF-kappaB-inducing kinase (NIK) in cytokine signaling remains controversial To identify the physiologic functions of NIK, we disrupted the NIK locus by gene targeting. Although NIK-/- mice displayed abnormalities in both lymphoid tissue development and antibody responses, NIK-/- cells manifested normal NF-kappaB DNA binding activity when treated with a variety of cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1), and lymphotoxin-beta (LT beta). However, NIK was selectively required for gene transcription induced through ligation of LT beta receptor but not TNF receptors. These results reveal that NIK regulates the transcriptional activity of NF-kappaB in a receptor-restricted manner.

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页码：2162 / 2165

页数：4

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