MAPKAP kinase-2:: Three's company at the G2 checkpoint

被引：6

作者：

Abraham, RT ^{[1
]}

机构：

[1] Burnham Inst, Signal Transduct Program, La Jolla, CA 92037 USA

来源：

MOLECULAR CELL | 2005年 / 17卷 / 02期

关键词：

D O I：

10.1016/j.molcel.2005.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Elegant studies in fission yeast by López-Avilés et al. (2005) and in mammalian cells by Manke et al. (2005) offer new insights into the mechanism through which stress-induced p38 activation inhibits mitotic entry in eukaryotic cells.

引用

页码：163 / 164

页数：2

共 7 条

[1] Checking on DNA damage in S phase [J].

Bartek, J ;

Lukas, C ;

Lukas, J .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (10) :792-804

[2] Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase [J].

Bulavin, DV ;

Higashimoto, Y ;

Popoff, IJ ;

Gaarde, WA ;

Basrur, V ;

Potapova, O ;

Appella, E ;

Fornace, AJ .

NATURE, 2001, 411 (6833) :102-107

[3] Regulating mammalian checkpoints through Cdc25 inactivation [J].

Donzelli, M ;

Draetta, GF .

EMBO REPORTS, 2003, 4 (07) :671-677

[4] G2 checkpoint control - Checking in to the last resort for DNA damage [J].

Jackson, JR ;

Zhou, BB .

CANCER BIOLOGY & THERAPY, 2004, 3 (03) :314-316

[5] MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation [J].

Manke, IA ;

Nguyen, A ;

Lim, D ;

Stewart, MQ ;

Elia, AEH ;

Yaffe, MB .

MOLECULAR CELL, 2005, 17 (01) :37-48

[6] The p38-mediated stress-activated checkpoint - A rapid response system for delaying progression through antephase and entry into mitosis [J].

Mikhailov, A ;

Shinohara, M ;

Rieder, CL .

CELL CYCLE, 2005, 4 (01) :57-62

[7] ATM and related protein kinases: Safeguarding genome integrity [J].

Shiloh, Y .

NATURE REVIEWS CANCER, 2003, 3 (03) :155-168

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