Chromosome aberrations in solid tumors

被引：578

作者：

Albertson, DG

Collins, C

McCormick, F

Gray, JW

机构：

[1] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[4] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

来源：

NATURE GENETICS | 2003年 / 34卷 / 04期

关键词：

D O I：

10.1038/ng1215

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

引用

收藏

页码：369 / 376

页数：8

相关论文

共 167 条

[1] Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement [J].

Abdel-Rahman, WM ;

Katsura, K ;

Rens, W ;

Gorman, PA ;

Sheer, D ;

Bicknell, D ;

Bodmer, WF ;

Arends, MJ ;

Wyllie, AH ;

Edwards, PAW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (05) :2538-2543

[2]

Aebi S, 1996, CANCER RES, V56, P3087

[3] Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene [J].

Albertson, DG ;

Ylstra, B ;

Segraves, R ;

Collins, C ;

Dairkee, SH ;

Kowbel, D ;

Kuo, WL ;

Gray, JW ;

Pinkel, D .

NATURE GENETICS, 2000, 25 (02) :144-146

[4] HOMOGENEOUSLY STAINING CHROMOSOMAL REGIONS CONTAIN AMPLIFIED COPIES OF AN ABUNDANTLY EXPRESSED CELLULAR ONCOGENE (C-MYC) IN MALIGNANT NEUROENDOCRINE CELLS FROM A HUMAN-COLON CARCINOMA [J].

ALITALO, K ;

SCHWAB, M ;

LIN, CC ;

VARMUS, HE ;

BISHOP, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (06) :1707-1711

[5] Telomere shortening and cell fates in mouse models of neoplasia [J].

Artandi, SE .

TRENDS IN MOLECULAR MEDICINE, 2002, 8 (01) :44-47

[6] A critical role for telomeres in suppressing and facilitating carcinogenesis [J].

Artandi, SE ;

DePinho, RA .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (01) :39-46

[7]

BAKER SJ, 1990, CANCER RES, V50, P7717

[8] Cancer - New-age tumour suppressors [J].

Balmain, A .

NATURE, 2002, 417 (6886) :235-237

[9] Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase [J].

Banerjee, D ;

Mayer-Kuckuk, P ;

Capiaux, G ;

Budak-Alpdogan, T ;

Gorlick, R ;

Bertino, JR .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2002, 1587 (2-3) :164-173

[10]

Bärlund M, 2000, CANCER RES, V60, P5340

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