3D-printed microfluidic automation

被引：252

作者：

Au, Anthony K. ^{[1
]}

Bhattacharjee, Nirveek ^{[1
]}

Horowitz, Lisa F. ^{[1
]}

Chang, Tim C. ^{[1
]}

Folch, Albert ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, 3720 15th Ave NE,Box 355061, Seattle, WA 98195 USA

来源：

LAB ON A CHIP | 2015年 / 15卷 / 08期

关键词：

EPOXY COMPONENTS; DIGITAL LOGIC; GENERATION; DEVICE;

D O I：

10.1039/c5lc00126a

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Microfluidic automation -the automated routing, dispensing, mixing, and/ or separation of fluids through microchannels - generally remains a slowly-spreading technology because device fabrication requires sophisticated facilities and the technology's use demands expert operators. Integrating microfluidic automation in devices has involved specialized multi-layering and bonding approaches. Stereolithography is an assembly-free, 3D-printing technique that is emerging as an efficient alternative for rapid prototyping of biomedical devices. Here we describe fluidic valves and pumps that can be stereolithographically printed in optically-clear, biocompatible plastic and integrated within microfluidic devices at low cost. User-friendly fluid automation devices can be printed and used by non-engineers as replacement for costly robotic pipettors or tedious manual pipetting. Engineers can manipulate the designs as digital modules into new devices of expanded functionality. Printing these devices only requires the digital file and electronic access to a printer.

引用

页码：1934 / 1941

页数：8

共 33 条

[1] Mail-order microfluidics: evaluation of stereolithography for the production of microfluidic devices [J].

Au, Anthony K. ;

Lee, Wonjae ;

Folch, Albert .

LAB ON A CHIP, 2014, 14 (07) :1294-1301

[2] The pumping lid: investigating multi-material 3D printing for equipment-free, programmable generation of positive and negative pressures for microfluidic applications [J].

Begolo, Stefano ;

Zhukov, Dmitriy V. ;

Selck, David A. ;

Li, Liang ;

Ismagilov, Rustem F. .

LAB ON A CHIP, 2014, 14 (24) :4616-4628

[3] Rapid prototyping of small size objects [J].

Bertsch, Arnaud ;

Renaud, Philippe ;

Vogt, Christian ;

Bernhard, Paul .

RAPID PROTOTYPING JOURNAL, 2000, 6 (04) :259-266

[4] Discrete elements for 3D microfluidics [J].

Bhargava, Krisna C. ;

Thompson, Bryant ;

Malmstadt, Noah .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (42) :15013-15018

[5]

Busch W, 2012, NAT METHODS, V9, P1101, DOI [10.1038/NMETH.2185, 10.1038/nmeth.2185]

[6]

Chantarapanich N., 2011, BIOM ENG INT C BMEIC, P104

[7] Multi-material microstereolithography [J].

Choi, Jae-Won ;

MacDonald, Eric ;

Wicker, Ryan .

INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY, 2010, 49 (5-8) :543-551

[8] Pressure driven digital logic in PDMS based microfluidic devices fabricated by multilayer soft lithography [J].

Devaraju, Naga Sai Gopi K. ;

Unger, Marc A. .

LAB ON A CHIP, 2012, 12 (22) :4809-4815

[9] Pneumatic oscillator circuits for timing and control of integrated microfluidics [J].

Duncan, Philip N. ;

Nguyen, Transon V. ;

Hui, Elliot E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (45) :18104-18109

[10] Large-scale investigation of the olfactory receptor space using a microfluidic microwell array [J].

Figueroa, Xavier A. ;

Cooksey, Gregory A. ;

Votaw, Scott V. ;

Horowitz, Lisa F. ;

Folch, Albert .

LAB ON A CHIP, 2010, 10 (09) :1120-1127

← 1 2 3 4 →