Can Platelet-Rich Plasma Enhance Anterior Cruciate Ligament and Meniscal Repair?

被引：47

作者：

Hutchinson, Ian D. ^{[1
]}

Rodeo, Scott A. ^{[2
]}

Perrone, Gabriel S. ^{[3
]}

Murray, Martha M. ^{[3
]}

机构：

[1] Wake Forest Baptist Hlth, Dept Orthopaed Surg, Winston Salem, NC USA

[2] Hosp Special Surg, Sports Med & Shoulder Serv, New York, NY 10021 USA

[3] Harvard Univ, Sch Med, Boston Childrens Hosp, Dept Orthopaed Surg, Boston, MA USA

来源：

JOURNAL OF KNEE SURGERY | 2015年 / 28卷 / 01期

关键词：

ACL; meniscus; PRP; biologics; meniscal repair; ACL reconstruction; DYNAMIC CONTACT MECHANICS; EXOGENOUS FIBRIN CLOT; NECROSIS-FACTOR-ALPHA; IN-VITRO; INTEGRATIVE REPAIR; GROWTH-FACTORS; KNEE OSTEOARTHRITIS; COLLAGEN SCAFFOLD; GENE-EXPRESSION; DOUBLE-BLIND;

D O I：

10.1055/s-0034-1387166

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

The use of platelet-rich plasma (PRP) to improve clinical outcome following a soft tissue injury, regeneration, and repair has been the subject of intense investigation and discussion. This article endeavors to relate clinical and basic science strategies focused on biological augmentation of the healing response in anterior cruciate ligament (ACL) and meniscus repair and replacement using PRP. Therein, a translational feedback loop is created in the literature and targeted towards the entire multidisciplinary team. Ultimately, it is hoped that the theoretical benefits of PRP on soft-tissue interfacial healing will emerge clinically following a careful, focused characterization at the benchtop, and prospective randomized controlled clinical study.

引用

页码：19 / 28

页数：10

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