Regenerative potential of embryonic renal multipotent progenitors in acute renal failure

被引：166

作者：

Lazzeri, Elena ^{[1
]}

Crescioli, Clara ^{[1
]}

Ronconi, Elisa ^{[1
]}

Mazzinghi, Benedetta ^{[1
]}

Sagrinati, Costanza ^{[1
]}

Netti, Giuseppe Stefano ^{[3
]}

Angelotti, Maria Lucia ^{[1
]}

Parente, Eliana ^{[1
]}

Ballerini, Lara ^{[1
]}

Cosmi, Lorenzo ^{[1
]}

Maggi, Laura ^{[1
]}

Gesualdo, Loreto ^{[3
]}

Rotondi, Mario ^{[1
,4
]}

Annunziato, Francesco ^{[1
]}

Maggi, Enrico ^{[1
]}

Lasagni, Laura ^{[1
]}

Serio, Mario ^{[1
]}

Romagnani, Sergio ^{[1
]}

Vannelli, Gabriella Barbara ^{[2
]}

Romagnani, Paola ^{[1
]}

机构：

[1] Univ Florence, Excellence Ctr Res, Transfer & High Educ Dev DE NOVO THEREPIES, Florence, Italy

[2] Univ Florence, Dept Anat, Florence, Italy

[3] Univ Foggia, Dept Biomed Sci, Foggia, Italy

[4] Fdn S Maugeri Ist Ricovero & Cura Carattere Sci, Dept Endocrinol & Internal Med, Pavia, Italy

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2007年 / 18卷 / 12期

关键词：

D O I：

10.1681/ASN.2007020210

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Bone marrow- and adult kidney-derived stem/progenitor cells hold promise in the development of therapies for renal failure. Here is reported the identification and characterization of renal multipotent progenitors in human embryonic kidneys that share CD24 and CD 133 surface expression with adult renal progenitors and have the capacity for self-renewal and multilineage differentiation. It was found that these CD24(+)CD133(+) cells constitute the early primordial nephron but progressively disappear during nephron development until they become selectively localized to the urinary pole of Bowman's capsule. When isolated and injected into SCID mice with acute renal failure from glycerol-induced rhabdomyolysis, these cells regenerated different portions of the nephron, reduced tissue necrosis and fibrosis, and significantly improved renal function. No tumorigenic potential was observed. It is concluded that CD24(+)CD133(+) cells represent a subset of multipotent embryonic progenitors that persist in human kidneys from early stages of nephrogenesis. The ability of these cells to repair renal damage, together with their apparent lack of tumorigenicity, suggests their potential in the treatment of renal failure.

引用

页码：3128 / 3138

页数：11

共 44 条

[1]

Stem cells in the kidney [J].