Molecular mechanisms of cholesterol absorption and transport in the intestine

被引：102

作者：

Hui, DY ^{[1
]}

Howles, PN ^{[1
]}

机构：

[1] Univ Cincinnati, Genome Res Inst, Dept Pathol, Cincinnati, OH 45237 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 02期

关键词：

lipase; cholesterol transporter; intracellular transport; post chylomicron transport vesicle;

D O I：

10.1016/j.semcdb.2005.01.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Many enzymes and transport proteins participate in cholesterol absorption. This review summarizes recent results on several proteins that are important for each step of the cholesterol absorption pathway, including the important roles of: (i) pancreatic triglyceride lipase (PTL), carboxyl ester lipase (CEL), and ileal bile acid transporter in determining the rate of cholesterol absorption; (ii) ATP binding cassette (ABC) transporters and the Niemann-Pick C-1 like-1 (NPC1L1) protein as intestinal membrane gatekeepers for cholesterol efflux and influx; and (iii) intracellular membrane vesicles and transport proteins in lipid trafficking through intracellular compartments prior to lipoprotein assembly and secretion to plasma circulation. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：183 / 192

页数：10

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