Melanocortin receptors and their accessory proteins

被引：63

作者：

Cooray, Sadani N. ^{[1
]}

Clark, Adrian J. L. ^{[1
]}

机构：

[1] Queen Mary Univ London, Ctr Endocrinol, William Harvey Res Inst, London EC1M 6BQ, England

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2011年 / 331卷 / 02期

基金：

英国医学研究理事会;

关键词：

MC1R; MC2R; MC3R; MC4R; MC5R; MRAP; MRAP2; MELANOCYTE-STIMULATING HORMONE; ACTIVITY-MODIFYING PROTEINS; FAMILIAL GLUCOCORTICOID DEFICIENCY; HUMAN ADRENOCORTICOTROPIN RECEPTOR; CYCLOPHILIN HOMOLOG NINAA; MOLECULAR-CLONING; ACTH RECEPTOR; FRAMESHIFT MUTATION; FUNCTIONAL-CHARACTERIZATION; CELL-LINE;

D O I：

10.1016/j.mce.2010.07.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The melanocortin receptor family consists of 5 members which belong to the GPCR superfamily. Their specific ligands, the melanocortins are peptide hormones which are formed by the proteolytic cleavage of the proopiomelanocortin (POMC) protein. It is now recognised that certain GPCRs require accessory proteins for their function. Like these GPCRs the melanocortin receptor family is also known to be associated with accessory proteins that regulate their function. In this review we will summarise the accessory proteins involved in the function of the 5 melanocortin receptors and in particular focus on the melanocortin 2 receptor accessory protein (MRAP) which is crucial for the function of the MC2R. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：215 / 221

页数：7

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