Does chronic hypoxia increase rat carotid body nitric oxide?

被引：21

作者：

Di Giulio, C

Grilli, A

De Lutiis, MA

Di Natale, F

Sabatino, G

Felaco, M

机构：

[1] Univ G DAnnunzio, Fac Med & Chirurg, Dipartimento Sci Biomed, I-66100 Chieti, Italy

[2] Univ G DAnnunzio, Sch Med, Inst Morphol Sci, I-66100 Chieti, Italy

[3] Univ G DAnnunzio, Sch Med, Inst Neonatol, I-66100 Chieti, Italy

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY | 1998年 / 120卷 / 02期

关键词：

chemoreceptor; carotid body; oxygen; nitric oxide; chronic hypoxia;

D O I：

10.1016/S1095-6433(98)00023-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The carotid body plays an important role in ventilatory adaptation during chronic hypoxia. Nitric oxide (NO) may act as a regulator in neurotransmission, influencing the carotid body chemosensory discharge. The aim of the study was to understand if NO could contribute to the adaptation process during chronic hypoxia. The rats were kept in chronic hypoxia (10-11% inspired oxygen) for 12 days, while the controls were kept in room air (21% O(2)). The distribution for diaphorase activity and immunohistochemistry for nitric oxide synthase (NOS) showed that chronic hypoxia induces an increase in NOS activity in the carotid body. It was concluded that NO release increased during chronic hypoxia and causes an inhibitory effect on carotid chemosensory discharge of the rat carotid body. (C) 1998 Elsevier Science Inc. All rights reserved.

引用

页码：243 / 247

页数：5

共 22 条

[1] HYPOVENTILATION AND PULMONARY HYPERTENSION IN CALVES AFTER CAROTID BODY EXCISION [J].