Preparation of 2-carboxy-3,4-substituted pyrrole haptens and synthesis of porphobilinogen

被引：8

作者：

Adamczyk, M

Reddy, RE

机构：

[1] Div. Organ. Chem. Res. (9NM, AP20), Diagnostics Division, Abbott Laboratories, Abbott Park, IL 60064-3500

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 14期

关键词：

D O I：

10.1016/0040-4039(96)00286-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Carboxy-3, 4-substituted pyrrole 1, the porphobilinogen (PBG, 2) like hapten was prepared via condensation of alpha-acetoxynitro compound (3) with benzyl isocyanoacetate (4) and further functional group transformations in good yields. Also, the hapten 1 was converted to PBG (2). Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2325 / 2326

页数：2

共 16 条

[1] A CONVENIENT AND VERSATILE SYNTHESIS OF PORPHOBILINOGEN [J].

ADAMCZYK, M ;

REDDY, RE .

TETRAHEDRON LETTERS, 1995, 36 (50) :9121-9124

[2]

AKTHAR M, 1979, COMPREHENSIVE ORGANI, V5

[3]

BARTON DHR, 1990, TETRAHEDRON, V46, P7587

[4] BIOSYNTHESIS OF PORPHYRINS AND RELATED MACROCYCLES .8. ENZYMIC DECARBOXYLATION OF UROPORPHYRINOGEN-III - STRUCTURE OF AN INTERMEDIATE, PHYRIAPORPHYRINOGEN-III, AND SYNTHESIS OF CORRESPONDING PORPHYRIN AND OF 2 ISOMERIC PORPHYRINS [J].

BATTERSBY, AR ;

HUNT, E ;

MCDONALD, E ;

PAINE, JB ;

SAUNDERS, J .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (09) :1008-1018

[5] BIOSYNTHESIS OF PORPHYRINS AND RELATED MACROCYLES .1. SYNTHESIS OF C-14-LABELED PYRROMETHANES [J].

BATTERSBY, AR ;

EVANS, DA ;

GIBSON, KH ;

MCDONALD, E ;

NIXON, L .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1973, (15) :1546-1556

[6]

COOKSON GH, 1953, BIOCHEM J, V57, P476

[7]

*EPA SCI ADV BOARD, 1990, EAPSABCASAC90002

[8]

FRYDMAN RB, 1978, PORPHYRINS, V6

[9] PURIFICATION AND PROPERTIES OF 5-AMINOLAEVULINATE DEHYDRATASE FROM HUMAN-ERYTHROCYTES [J].

GIBBS, PNB ;

CHAUDHRY, AG ;

JORDAN, PM .

BIOCHEMICAL JOURNAL, 1985, 230 (01) :25-34

[10]

LASH TD, 1994, SYNTHESIS-STUTTGART, P170

← 1 2 →