Synthesis of enantiopure 3,4-disubstituted piperidines. An asymmetric synthesis of (+)-paroxetine

被引：31

作者：

Amat, M

Hidalgo, J

Bosch, J

机构：

[1] Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 06期

关键词：

D O I：

10.1016/0957-4166(96)00189-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An asymmetric synthesis of the 3,4-trans-disubstituted piperidine derivative (+)-paroxetine from the chiral non racemic lactam 1 is reported. The p-fluorophenyl substituent is introduced by conjugate addition to the unsaturated lactams 3 whereas the aryloxymethyl substituent at the 3-position is assembled by taking advantage of the activating alkoxycarbonyl group of 3. (C) 1996 Elsevier Science Ltd

引用

页码：1591 / 1594

页数：4

共 10 条

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