Adult type 2 diabetes induced by intrauterine growth retardation

被引：19

作者：

Wolf, G ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Nutrit Sci & Toxicol, Berkeley, CA 94720 USA

来源：

NUTRITION REVIEWS | 2003年 / 61卷 / 05期

关键词：

obesity; uteroplacental insufficiency; diabetes; pancreas; beta cells; hyperglycemia;

D O I：

10.1301/nr.2003.may.176-179

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The association of low birth weight with increased risk of adult obesity and type 2 diabetes observed in, epidemiologic studies in humans was replicated in an animal model. This was achieved by bilateral uterine artery ligation in pregnant rats, which, resulted in uteroplacental insufficiency. The affected offspring were found to develop obesity, insulin resistance, and hyperglycemia-all of which are,signs of type 2 diabetes-at 26 weeks of age. Reprogramming of the developing pancreatic beta-cells might have caused this effect, which lasted into adulthood.

引用

页码：176 / 179

页数：4

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