Illusory Misidentifications and Cortical Hypometabolism in Parkinson's Disease

被引：23

作者：

Ishioka, Toshiyuki ^{[1
]}

Hirayama, Kazumi ^{[1
]}

Hosokai, Yoshiyuki ^{[1
]}

Takeda, Atsushi ^{[2
]}

Suzuki, Kyoko ^{[1
]}

Nishio, Yoshiyuki ^{[1
]}

Sawada, Yoichi ^{[1
]}

Takahashi, Shoki ^{[3
]}

Fukuda, Hiroshi ^{[4
]}

Itoyama, Yasuto ^{[2
]}

Mori, Etsuro ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Behav Neurol & Cognit Neurosci, Sendai, Miyagi 980, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Neurol, Sendai, Miyagi 980, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Diagnost Radiol, Sendai, Miyagi 980, Japan

[4] Tohoku Univ, Inst Dev Aging & Canc, Dept Nucl Med & Radiol, Sendai, Miyagi 980, Japan

来源：

MOVEMENT DISORDERS | 2011年 / 26卷 / 05期

关键词：

Parkinson's disease; illusory misidentification; visual cortices; positron emission tomography; overlapping figure identification test; MILD COGNITIVE IMPAIRMENT; CEREBRAL-BLOOD-FLOW; VISUAL HALLUCINATIONS; LEWY BODIES; VISUOPERCEPTUAL IMPAIRMENT; DEMENTIA; BRAIN; RECOGNITION; PERCEPTION; ATTENTION;

D O I：

10.1002/mds.23576

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Idiopathic Parkinson's disease (PD) is associated with documented impairments in various visual functions. However, there have been only a limited number of studies that have reported on the brain regions responsible for impairment of visual recognition in PD. In our study, we evaluated the performance of PD patients and 24 healthy controls on the Poppelreuter-type overlapping figure identification test to investigate the impairment of visual recognition. We also measured the PD patients' resting cerebral glucose metabolism using (18)F-fluorodeoxyglucose positron emission tomography and investigated the relationship between the impairment of visual recognition and cortical hypometabolism. The PD patients had substantial and frequent illusory responses in the overlapping figure identification test, and their illusory misidentifications were correlated with hypometabolism in the visual cortices, including the right inferior temporal gyrus and the bilateral temporo-parieto-occipital junction. These findings suggest that PD patients have impaired visual recognition characterized by illusory misidentifications of visual stimuli, which could be attributed to dysfunction of the visual cortices. (C) 2011 Movement Disorder Society

引用

页码：837 / 843

页数：7

共 47 条

[1]

Do parkinsonian patients have trouble telling lies The neurobiological basis of deceptive behaviour [J].