Prospects for stem cell-based therapy

被引：230

作者：

Daley, George Q. ^{[1
,2
,3
,6
]}

Scadden, David T. ^{[3
,4
,5
]}

机构：

[1] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[3] Harvard Univ, Stem Cell Inst, Boston, MA 02115 USA

[4] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02115 USA

[5] Harvard Univ, Dept Stem Cell & regenerat Biol, Boston, MA 02115 USA

[6] Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

CELL | 2008年 / 132卷 / 04期

关键词：

HEMATOPOIETIC STEM; PROGENITOR CELLS; FIBROBLASTS; POPULATION; RECEPTORS; REJECTION; MIGRATION; LINES;

D O I：

10.1016/j.cell.2008.02.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Resident pools of somatic stem cells in many organs are responsible for tissue maintenance and repair. The goal of regenerative medicine is to exploit these cells either by transplanting them from an exogenous source or by activating endogenous stem cells pharmacologically. For diseases caused by mutations in a single gene, the therapeutic goal is tissue replacement using stem cells engineered to correct the genetic defect. However, a number of technical hurdles must be overcome before therapies based on pluripotent human stem cells can enter the clinic.

引用

页码：544 / 548

页数：5

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